Physiology
Oxygen-Haemoglobin Dissociation Curve
- Sigmoid shape: oxygen binding alters the protein shape to promote binding
- Increased dissociation (curve moves right):
- CO2 rise
- Temperature rise
- pH decreased (hydrogen ion rise)
- Increased 2,3-DPG
- Fetal haemoglobin has a higher affinity for oxygen: the curve lies left
- Myoglobin…