Pharmacology
Immunosuppressants
- Ciclosporin A (calcineurin inhibitor) and Tacrolimus:
- Inhibit IL-2 production
- Do not cause bone marrow suppression
- SEs: nephrotoxicity, tremor, hirsutism and gingival hypertrophy
- Contraindicated in uncontrolled hypertension (dose-related increase in BP)
- Purine antagonists: azathioprine and MMF
- Blocks RNA and DNA synthesis