Ocular Cicatricial Pemphigoid

Pathophysiology

• Autoantibodies directed against bullous pemphigoid antigen II (BP180) in the basement membrane zone

Clinical features

• Generally bilateral

• Inferior forniceal depth of less than 8mm

• Early findings

  • Acute papillary conjunctivitis
  • Medial canthal keratinization
  • Trichiasis

• Symblepharon

• Ankyloblepharon

• Late stage: secondary corneal…